ORAL HYOSCINE BUTYLBROMIDE DOES NOT ALTER THE PATTERN OF SMALL INTESTINAL MOTOR ACTIVITY

Effects of oral cyclotropium bromide, hyoscine N-butylbromide and placebo on gastric emptying and antral motor activity in healthy man.

Cyclotropium bromide, a new antimuscarinic agent, inhibits gastrointestinal motility in animals at lower doses than those required to inhibit gastric acid secretion and salivation. In man, cyclotropium bromide suppresses fasting and meal stimulated colonic motility. This study investigated the effects of single oral doses of 60 mg cyclotropium bromide, 60 mg hyoscine N-butylbromide and placebo ...

Regional Differences in Motor Responsivenes to Hyoscine Butylbromide in Rabbit Isolated Small and Large Intestine

The effect of hyoscine butylbromide (scopolamine butylbromide), a competitive nonselective antagonist of acetylcholine at muscarinic receptors, on the isolated rabbit duodenum, ileum and colon was investigated. Hyoscine butylbromide (9×10M 9×10M) decreased in a concentration-dependent manner the amplitude of the spontaneous pendular movements of the rabbi-isolated duodenum (r=0.99; p<0.001), il...

Studies on the development of rapidly disintegrating hyoscine butylbromide tablets.

The objective of this study was to prepare hyoscine butylbromide (a drug with bitter taste) tablets that can rapidly disintegrate in saliva. The granules were prepared by the extrusion method using aminoalkyl methacrylate copolymers (Eudragit E-100). The drugs dissolved rapidly in medium at pH 1.2 in a dissolution test while none of the drugs dissolved from the granules (% of dissolved < 5%) ev...

pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal spasms

Abdominal pain is one of the most common reasons why people seek medical care, and is often due to spasm of intra-abdominal visceral organs. Hyoscine butylbromide (HBB) is a quaternary ammonium compound which blocks the action of acetylcholine at parasympathetic sites (both muscarinic and nicotinic receptors) in smooth muscle, and in secretory glands. It causes decreased motility of the gastroi...

Effect of hyoscine butylbromide on cervical dilation during labor